Synthetic strategies to epoxydiynes and a key synthon of the neocarzinostatin chromophore
β Scribed by Thominet, Olivier; Baker, James R.; Britton, Hugh; Etheridge, Zac C.; Soscia, Marco G.; Caddick, Stephen
- Book ID
- 119995918
- Publisher
- Royal Society of Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 277 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B711196G
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π SIMILAR VOLUMES
The 6-ring/10-ring dienediyne model 11 of the antitumor agent neocarzinostatin chromophore 1 and its 6-ring/11-ring homolog 12 have been obtained in 41 and 18% yields, respectively, by McMurry cyclizations of ketoaldehydes 8 and 9 using TiCl 3 ΠΈ2DME and Zn/Cu couple. Compounds 8 and 9 were obtained
## Summery: A convenient method for the synthesis of [3]-cumulenes based on a Uorner-Emmons type reaction of allenyldiphenylphosphine oxides with aldehydes or ketones has been describ'ed. A facile two-step synthesis of eneynecumulenes has been accomplished by this method. Neocarzinostatin chromoph
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