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A McMurry Route to the Dienediyne Portion of Models of the Neocarzinostatin Chromophore

✍ Scribed by Elisabeth Rank; Reinhard Brückner

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
638 KB
Volume
1998
Category
Article
ISSN
1434-193X

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✦ Synopsis

The 6-ring/10-ring dienediyne model 11 of the antitumor agent neocarzinostatin chromophore 1 and its 6-ring/11-ring homolog 12 have been obtained in 41 and 18% yields, respectively, by McMurry cyclizations of ketoaldehydes 8 and 9 using TiCl 3 и2DME and Zn/Cu couple. Compounds 8 and 9 were obtained by multistep syntheses starting from the

📜 SIMILAR VOLUMES

ChemInform Abstract: A McMurry Route to
ChemInform Abstract: A McMurry Route to the Dienediyne Portion of Models of the Neocarzinostatin Chromophore.
✍ E. RANK; R. BRUECKNER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

First generation of the dienediyne porti
First generation of the dienediyne portion of a dienediyne model of the neocarzinostatin chromophore by a McMurry reaction
✍ Mark Rucker; Reinhard Brückner 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 243 KB

The first 3--->6 type ring-closing dienediyne synthesis by means of a McMurry reaction was realized by converting the ketoaldehyde 20 into the 6-/10-membered bicyclic dienediyne 22. Diastereoselective pinacol couplings 20--->23 and 21--~24 giving 6-/10-membered bicyclic enediynediols were possible,