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Synthetic fragments and analogues of elastin. II. Conformational studies

✍ Scribed by A. M. Tamburro; V. Guantieri; L. Pandolfo; A. Scopa

Publisher
Wiley (John Wiley & Sons)
Year
1990
Tongue
English
Weight
766 KB
Volume
29
Category
Article
ISSN
0006-3525

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✦ Synopsis

Conformational studies on synthetic repetitive sequences and analogues of elastin are described.

C D and nmr measurements gave evidence of flexible ,&turns as the dominant structural feature whose stability was found t o decrease by increasing the number of repetitivc units. The sequences comprised the structural unit Gly-X-Gly ( X = Val, Leu, Ala), with X-Gly or Gly-Gly located at the corners of t h e bend.

Based on that, it is proposed t h a t these regions of elastin, unlike the proline-containing sequences, contribute t o the elasticity of the protein through a classical mechanism in terms of the rotational isomeric state theory.

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