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Synthetic fragments and analogues of elastin. I. The synthesis

✍ Scribed by V. Guantieri; S. Grando; L. Pandolfo; A. M. Tamburro

Publisher
Wiley (John Wiley & Sons)
Year
1990
Tongue
English
Weight
635 KB
Volume
29
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The synthesis of some repetitive sequences of elastin and their simplified analogues, all comprising the structural unit Gly‐X‐Gly (X = Val, Leu, Ala), is described. In particular, the following peptides and polypeptides were synthesized and characterized: Boc‐Gly‐Val‐Gly‐Gly‐Leu‐OMe, Boc‐Gly‐Leu‐Gly‐Gly‐Val‐OMe, Boc‐(Gly‐Val‐Gly‐Gly‐Leu)~2~‐OMe, Boc‐(Gly‐Val‐Gly‐Gly‐Leu)~3~‐OMe, Boc‐Gly‐Val‐Gly‐Gly‐OEt, Boc‐Leu‐Gly‐Gly‐Leu‐OMe, Boc‐Val‐Gly‐Gly‐Val‐OMe, poly(Ala‐Gly‐Gly), poly(Val‐Gly‐Gly), and poly (Leu‐Gly‐Gly).

In every case, the synthesis was accomplished by classical procedures in solution, by using the p‐nitrophenyl ester method for the polycondensation step, and the mixed anhydride or the azide methods for the coupling steps.

📜 SIMILAR VOLUMES

Synthetic fragments and analogues of ela
Synthetic fragments and analogues of elastin. II. Conformational studies
✍ A. M. Tamburro; V. Guantieri; L. Pandolfo; A. Scopa 📂 Article 📅 1990 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 766 KB

Conformational studies on synthetic repetitive sequences and analogues of elastin are described. C D and nmr measurements gave evidence of flexible ,&turns as the dominant structural feature whose stability was found t o decrease by increasing the number of repetitivc units. The sequences comprised