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Biological and conformational studies on analogues of a synthetic peptide enhancing HIV-1 infection

✍ Scribed by Monica Dettin; Claudia Scarinci; Carlo Zanotto; Rossella Roncon; Anita De Rossi; Carlo Di Bello

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 153 KB
Volume: 4
Category: Article
ISSN: 1075-2617
DOI: 10.1002/(sici)1099-1387(199811)4:7<436::aid-psc163>3.0.co;2-c

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✦ Synopsis

We have previously demonstrated that a 23-amino acid peptide derived from the V3 loop of the surface glycoprotein of the HIV-1 strain MN is able to bind CD4 and to enhance HIV-1 infection. Further studies have suggested that the peptide/CD4 interaction induces an increase in both CD4 expression and CD4/gp120 binding affinity. This paper describes the biological and physico-chemical characterization of three analogues of reduced sequence that have been designed in order to identify the minimum active sequence of this peptide corresponding to the MN-HIV- 1 principal neutralizing domain. Biological studies indicate that the entire sequence is required for biological activity and that the sequence 1-18 presents an inhibitory activity. CD and FT-IR absorption data are discussed here in order to identify possible structure-function correlations.

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