A highly efficient synthesis of a tetracyclic intermediate 2 to the antitumor antibiotics AX-2 4, mitomycin A 2, and C \_l\_ is described. Mitomycin C 1 is one of the most effective antitumor agents currently used for chemotherapy.1
Synthetic approaches toward naphthyridinomycin. I. Stereoselective synthesis of a tetracyclic intermediate.
β Scribed by Tohru Fukuyama; Alison A Laird
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 195 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A highly stereoselective synthesis of a tetracyclic intermediate 2 to the quinone antitumor antibiotic naphthyridinomycin I_ is described.
π SIMILAR VOLUMES
An efficient synthesis of the tetracyclic core of nakadomarin A was accomplished starting from methyl 4-oxo-3-piperidinecarboxylate. The key steps were intramolecular cyclization of furan to N-acyliminium ions to construct the strained central cyclopentene ring.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
In 1968, we described the synthesis of the tetracyclic vinylogous amide(g) n