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Synthetic approach towards nakadomarin A: efficient synthesis of the central tetracyclic core

✍ Scribed by Toshiaki Nagata; Atsushi Nishida; Masako Nakagawa

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 94 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01792-0

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✦ Synopsis

An efficient synthesis of the tetracyclic core of nakadomarin A was accomplished starting from methyl 4-oxo-3-piperidinecarboxylate. The key steps were intramolecular cyclization of furan to N-acyliminium ions to construct the strained central cyclopentene ring.

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