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Synthetic approaches toward mitomycins. I. Stereoselective synthesis of a tetracyclic intermediate.

✍ Scribed by Tohru Fukuyama; Lihu Yang

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 134 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)87791-6

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✦ Synopsis

A highly efficient synthesis of a tetracyclic intermediate 2 to the antitumor antibiotics AX-2 4, mitomycin A 2, and C _l_ is described. Mitomycin C 1 is one of the most effective antitumor agents currently used for chemotherapy.1

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