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Synthesis, Structure Analysis, and Antitumor Activity of (R)-2,4-Dioxo-5-fluoro-1-[1-(methoxycarbonyl) Ethylaminocarbonylmethyl]-1,2,3,4-tetrahydropyrimidine

✍ Scribed by Ji-Xin Yuan; Xiao-Qing Cai; Di-Mei Chen; Mao-Lin Hu

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 125 KB
Volume: 25
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.200790080

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✦ Synopsis

A new dipeptide compound, (R)-2,4-dioxo-5-fluoro-1-[1-(methoxycarbonyl) ethylaminocarbonylmethyl]-1,2,3, 4-tetrahydropyrimidine (5-FUAPM), has been synthesized and identified by means of elemental analysis, IR, 1 H NMR and 13 C NMR spectra. The single crystal of compound 5-FUAPM•DMF was also obtained and characterized by DSC-TGA techniques. The crystal belongs to orthorhombic space group P2 1 2 1 2 1 with the cell parameters: a＝ 0.4740(7) nm, b＝1.923(3) nm, c＝1.9229 nm, α＝β＝γ＝90°, V＝1.753 nm 3 , Z＝4, D c ＝1.312 g/cm 3 , M r ＝346.32, F(000)＝728 and µ＝0.111 mm -1 . The final R and wR are 0.1378 and 0.2862, respectively. The result of the biological test showed that the compound 5-FUAPM has certain antitumor activities.

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