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Synthesis, stereoselective enzymatic hydrolysis, and skin permeation of diastereomeric propranolol ester prodrugs

✍ Scribed by Chandrasekhar Udata; Giridhar Tirucherai; Ashim K. Mitra

Book ID
109389194
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
86 KB
Volume
88
Category
Article
ISSN
0022-3549

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πŸ“œ SIMILAR VOLUMES

Characterization of esterases involved i
Characterization of esterases involved in the stereoselective hydrolysis of ester-type prodrugs of propranolol in rat liver and plasma
✍ Yasushi Yoshigae; Teruko Imai; Megumi Taketani; Masaki Otagiri πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 84 KB πŸ‘ 1 views

An inhibition study showed that the stereoselective hydrolysis of butyryl propranolol (butyryl PL) in rat liver microsomes and plasma involves carboxylesterase. The hydrolysis of (S)-butyryl PL in plasma was specifically inhibited by eserine and bis-nitrophenyl phosphate (BNPP), compared to the (R)-