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Stereoselective Enzymatic Hydrolysis of Various Ester Prodrugs of Ibuprofen and Flurbiprofen in Human Plasma
✍ Scribed by Niels Mørk; Hans Bundgaard
- Book ID
- 110343314
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 789 KB
- Volume
- 09
- Category
- Article
- ISSN
- 0724-8741
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An inhibition study showed that the stereoselective hydrolysis of butyryl propranolol (butyryl PL) in rat liver microsomes and plasma involves carboxylesterase. The hydrolysis of (S)-butyryl PL in plasma was specifically inhibited by eserine and bis-nitrophenyl phosphate (BNPP), compared to the (R)-