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Ester Prodrugs of Flurbiprofen: Synthesis, Plasma Hydrolysis and Gastrointestinal Toxicity.

✍ Scribed by Rhea Mohan; C. S. Ramaa


Publisher
John Wiley and Sons
Year
2007
Weight
20 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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An inhibition study showed that the stereoselective hydrolysis of butyryl propranolol (butyryl PL) in rat liver microsomes and plasma involves carboxylesterase. The hydrolysis of (S)-butyryl PL in plasma was specifically inhibited by eserine and bis-nitrophenyl phosphate (BNPP), compared to the (R)-