✦ LIBER ✦

Synthesis, Stability, Antiviral Activity, and Protease-Bound Structures of Substrate-Mimicking Constrained Macrocyclic Inhibitors of HIV-1 Protease

✍ Scribed by Tyndall, Joel D. A.; Reid, Robert C.; Tyssen, David P.; Jardine, Darren K.; Todd, Belinda; Passmore, Margaret; March, Darren R.; Pattenden, Leonard K.; Bergman, Douglas A.; Alewood, Dianne

Book ID: 111910496
Publisher: American Chemical Society
Year: 2000
Tongue: English
Weight: 518 KB
Volume: 43
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm000013n

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and activity of conformational

Synthesis and activity of conformationally-constrained macrocyclic norstatine-based inhibitors of HIV protease

✍ Jian Jeffrey Chen; Peter J. Coles; Lee D. Arnold; Roger A. Smith; I. David MacDo 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 235 KB

Structure-activity relationships for mac

Structure-activity relationships for macrocyclic peptidomimetic inhibitors of HIV-1 protease

✍ G. Abbenante; D.A. Bergman; R.I. Brinkworth; D.R. March; R.C. Reid; P.A. Hunt; I 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 261 KB

A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents an

Synthesis and Antiviral Activity of P1′

Synthesis and Antiviral Activity of P1′ Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors.

✍ Peggy P. Huang; John T. Randolph; Larry L. Klein; Sudthida Vasavanonda; Tatyana 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

Synthesis and antiviral activity of P1′

Synthesis and antiviral activity of P1′ arylsulfonamide azacyclic urea HIV protease inhibitors

✍ Peggy P Huang; John T Randolph; Larry L Klein; Sudthida Vasavanonda; Tatyana Dek 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 321 KB

Synthesis, antiviral activity and pharma

Synthesis, antiviral activity and pharmacokinetics of P1/P1′ substituted 3-aminoindazole cyclic urea HIV protease inhibitors

✍ Robert F Kaltenbach III; Mona Patel; Robert E Waltermire; Gregory D Harris; Benj 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 126 KB

Synthesis, Antiviral Activity and Pharma

Synthesis, Antiviral Activity and Pharmacokinetics of P1/P1′ Substituted 3-Aminoindazole Cyclic Urea HIV Protease Inhibitors.

✍ Robert F. III Kaltenbach; et al. et al. 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 22 KB 👁 1 views