Synthesis and activity of conformationally-constrained macrocyclic norstatine-based inhibitors of HIV protease
✍ Scribed by Jian Jeffrey Chen; Peter J. Coles; Lee D. Arnold; Roger A. Smith; I. David MacDonald; Julie Carrière; Allen Krantz
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 235 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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📜 SIMILAR VOLUMES
A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents an
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