Synthesis, Reactivity, and Application as Chiral Auxiliaries of the novel (3R)- and (3S)-4,5-dihydro-3-hydroxy-4,4,5,5-tetramethyl-3-phenylfuran-2(3H)-ones in the Paterno-Büchi reaction
✍ Scribed by Thomas Oppenländer; Peter Schönholzer
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- German
- Weight
- 548 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
- BuLI, THF, r.t , 24 h 2) (-)-camphanay1 chloride
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The novel 4-amino-or 4-aryl-substituted 2,4-dihydro-5-[(4-trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-ones 3a -3g were synthesized by reaction of N-(ethoxycarbonyl)-4-(trifluoromethyl)benzenehydrazonic acid ethyl ester (2) and primary amines or hydrazine by microwave irradiation. Compounds 3a -3g wer