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Generation of 6,7-Dihydro-5H-1,3,4-thiadiazolo[3,2-a]pyridines — Unexpected Products in the Reaction of 5-Ethylthio-1,3,4-thiadiazole-2-amine and 3-(Dimethylamino)propiophenones

✍ Scribed by Jairo Quiroga; Braulio Insuasty; Pedro Hernandez; Rodolfo Moreno; Regina H. de Almeida; Herbert Meier

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
447 KB
Volume
1998
Category
Article
ISSN
1434-193X

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✦ Synopsis

pyridines 4a-e was prepared by the reaction of 5-ethylthio-1,3,4-thiadiazole-2-amine (1) and p-substituted 3-(dimeth-1,3,4-Thiadiazoles find a variety of applications as antibiotic, antiinflammatory or bacteriostatic agents and as pesticides [1] [2] . These biological activities have stimulated us to synthesize and investigate a new class of fused 1,3,4-thiadiazoles. Based on our experience [3] [4] [5] [6] with the reaction Scheme 1

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