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Microwave-Assisted Synthesis of Novel 2,4-Dihydro-5-[4-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-ones and Potentiometric Determination of Their pKa in Nonaqueous Solvents

✍ Scribed by Musa Özil; Fatih İslamoğlu; Emre Menteşe; Bahittin Kahveci

Publisher: John Wiley and Sons
Year: 2010
Tongue: German
Weight: 231 KB
Volume: 93
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201000002

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✦ Synopsis

The novel 4-amino-or 4-aryl-substituted 2,4-dihydro-5-[(4-trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-ones 3a -3g were synthesized by reaction of N-(ethoxycarbonyl)-4-(trifluoromethyl)benzenehydrazonic acid ethyl ester (2) and primary amines or hydrazine by microwave irradiation. Compounds 3a -3g were potentiometrically titrated with tetrabutylammonium hydroxide (Bu 4 NOH) in four nonaqueous solvents, i.e., i PrOH, t BuOH, MeCN, and N,N-dimethylformamide (DMF). Also half-neutralization potential values and the corresponding pK a values were determined in all cases.

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