✍ Scribed by Lindel, Thomas ;Hoffmann, Holger
No coin nor oath required. For personal study only.
The alkylidene hydantoin 8 was synthesized as an analogue of the marine natural product oroidin (1) by employing a Horner‐Wadsworth‐Emmons reaction. Treatment of 8 with bromine in acetic acid induced a biomimetic spiro‐cyclization forming the ACD ring system of dibromophakellin (2) in one step. rac‐Midpacamide (10) was obtained from the same precursor through a chemoselective, ruthenium‐catalyzed hydrogenation leaving the brominated pyrrole moiety intact.
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## Abstract The first synthesis of racemic silyhermin (__rac__‐1a) and its 2‐diastereomers 1b (as a ca. 1:1 mixture) was accomplished by starting from caffeic acid ethyl ester and coniferyl alcohol.
Poly(o-phenyleneditelluride) 6 has been prepared by the reduction of I ,2-bis(trichlorotelluro)benzene obtained by treatment of 1,2-bis(trimethylsilyI)benzene with TeC14. The reduction of 6 with NaBH4 in ethanol solution affords sodium benzene-l,2-ditellurolate, which, upon treatment with methylene