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ChemInform Abstract: Synthesis of rac-Midpacamide and the spiro-Cyclization of Its Precursor.

✍ Scribed by T. LINDEL; H. HOFFMANN


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
28
Category
Article
ISSN
0931-7597

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Synthesis ofrac-Midpacamide and thespiro
✍ Lindel, Thomas ;Hoffmann, Holger πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 488 KB

## Abstract The alkylidene hydantoin 8 was synthesized as an analogue of the marine natural product oroidin (1) by employing a Horner‐Wadsworth‐Emmons reaction. Treatment of 8 with bromine in acetic acid induced a biomimetic __spiro__‐cyclization forming the ACD ring system of dibromophakellin (2)