Synthesis ofrac-Midpacamide and thespiro
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Lindel, Thomas ;Hoffmann, Holger
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Article
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1997
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John Wiley and Sons
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English
β 488 KB
## Abstract The alkylidene hydantoin 8 was synthesized as an analogue of the marine natural product oroidin (1) by employing a HornerβWadsworthβEmmons reaction. Treatment of 8 with bromine in acetic acid induced a biomimetic __spiro__βcyclization forming the ACD ring system of dibromophakellin (2)