Total Synthesis ofrac-Silyhermin and Its 2-Diastereomers of Potential Antihepatotoxic Activity
✍ Scribed by Antus, Sándor ;Baitz-Gács, Eszter ;Gottsegen, Ágnes ;Seligmann, Otto ;Wagner, Hildebert
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 374 KB
- Volume
- 1993
- Category
- Article
- ISSN
- 0947-3440
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The first synthesis of racemic silyhermin (rac‐1a) and its 2‐diastereomers 1b (as a ca. 1:1 mixture) was accomplished by starting from caffeic acid ethyl ester and coniferyl alcohol.
📜 SIMILAR VOLUMES
## Abstract A nine‐step gram‐scale total synthesis of all four diastereomers 3–6 of 2‐acetamido‐2,4‐dideoxy‐D‐hexapyranose from aldehyde 9, a known derivative of (__S__)‐malic acid, is described.
pears downfield at 6 7. 77 (cf., 7.82 in IIb) and one of the methoxy groups appears upfield a t 6 3.68 (cf., 3.60 in IIb), a methoxy can be placed at C-1 and a hydrogen a t C-11 (5, 10, 11)6. The UV spectrum [A,,, ( C H 3 O H ) nm (log 6): 217 (4.65), 280 (4.08),307 (4.16), and 313 sh (4.16)] is cha