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Total synthesis of all four diastereomers of 2-acetamido-2,4-dideoxy-D-hexapyranose as potential competitive inhibitors ofN-acetylneuraminic acid synthase

✍ Scribed by Mulzer, Johann ;Seilz, Carsten ;Luger, Peter ;Weber, Manuela ;Reutter, Werner


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
941 KB
Volume
1991
Category
Article
ISSN
0947-3440

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✦ Synopsis


Abstract

A nine‐step gram‐scale total synthesis of all four diastereomers 3–6 of 2‐acetamido‐2,4‐dideoxy‐D‐hexapyranose from aldehyde 9, a known derivative of (S)‐malic acid, is described.