Synthesis of Δ2-Isoxazoline fatty acid ester heterocycles
✍ Scribed by James A. Kenar; Sevim Z. Erhan
- Book ID
- 107490215
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 104 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0003-021X
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📜 SIMILAR VOLUMES
Solid-phase synthesis of A2-isoxazolines through a 1,3-dipolar cycioaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophiles to afford A2-isoxazolines in good yields.
The preparation of highly substituted J-hydroxy carbonyl compounds from isoxazolines is featured in a synthesis of crispatic acid. A J-hydroxy imine, the proposed intermediate in this transformation, is isolated for the first time and a stereoselective hydroboration of a 5-vinyl substituted isoxazol