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Synthesis of γ-fluoro-α-methyl-α-amino acids. A new alkylation procedure for ester imines

✍ Scribed by Günter Haufe; Klaus Wilhelm Laue; Michael Ulrich Triller; Yoshio Takeuchi; Norio Shibata

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
568 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

Deprotonation of alanine ester imines with KO'Bu in DMSO or DMF and alkylation of the formed enolates with several 2-fluoroalkyl halogenides 2 and subsequent hydrolysis of the imino and the ester groups are presented as an efficient three-step sequence for the synthesis of racemic title compounds 5.

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