γ-Oxo-α,β-unsaturated δ-lactones and lactams, which are in high yields, of the corresponding α-amino-γ-oxo-α,βunsaturated δ-lactones and -lactams, compounds of great easily accessible from their corresponding 2-furylcarbinols, were used as substrates for the 1,4-reductive addition of biological and
The Photochemistry of N-Phthaloyl α-Amino Acid Esters: A New Approach to β,γ-Unsaturated α-Amino Acids and Dihydrobenzazepinediones
✍ Scribed by Priv.-Doz. Dr. Axel G. Griesbeck; Dipl.-Chem. Harald Mauder
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 445 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0044-8249
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The catalytic and asymmetric nitro-Mannich reaction of nitro compounds to α-imino esters catalyzed by chiral bisoxazoline-copper complexes [Eq. (1); Pg = protecting group] gave β-nitro-α-amino esters with excellent diastereo- and enantioselectivities. The reactions can be performed under ambient con
The development of CÀC bond-forming reactions that create two new stereogenic centers with high diastereo-and enantioselectivity in a single step can open new routes to highly valuable optically active compounds. The catalytic enantioselective addition to imines [1] belongs to this class of importan