𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Catalytic Enantioselective Addition of Nitro Compounds to Imines—A Simple Approach for the Synthesis of Optically Active β-Nitro-α-Amino Esters

✍ Scribed by Nagatoshi Nishiwaki; Kristian Rahbek Knudsen; Kurt V. Gothelf; Karl Anker Jørgensen

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
102 KB
Volume
40
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

✦ Synopsis

The catalytic and asymmetric nitro-Mannich reaction of nitro compounds to α-imino esters catalyzed by chiral bisoxazoline-copper complexes [Eq. (1); Pg = protecting group] gave β-nitro-α-amino esters with excellent diastereo- and enantioselectivities. The reactions can be performed under ambient conditions.

📜 SIMILAR VOLUMES

Catalytic Enantioselective Addition of N
Catalytic Enantioselective Addition of Nitro Compounds to Imines—A Simple Approach for the Synthesis of Optically Active β-Nitro-α-Amino Esters
✍ Nagatoshi Nishiwaki; Kristian Rahbek Knudsen; Kurt V. Gothelf; Karl Anker Jørgen 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 2 views

The development of CÀC bond-forming reactions that create two new stereogenic centers with high diastereo-and enantioselectivity in a single step can open new routes to highly valuable optically active compounds. The catalytic enantioselective addition to imines [1] belongs to this class of importan