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Asymmetric synthesis of α-alkyl α-amino acids by alkylation of a chiral amidine ester

✍ Scribed by Michael Kolb; Jacqueline Barth

Publisher: Elsevier Science
Year: 1979
Tongue: French
Weight: 201 KB
Volume: 20
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)70994-4

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✦ Synopsis

A short and convenient asymmetric synthesis of cl-alkyl a-amino acids is described, using (S)(-)-I-dimethoxymethyl-Z-methoxymethyl pyrrolidine (5) as chiral auxiliary reagent.

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