## Abstract For Abstract see ChemInform Abstract in Full Text.
Alkylation of chiral phosphonoglycine equivalents: Asymmetric synthesis of diethyl α-amino-α-alkyl-phosphonates
✍ Scribed by Giulia Cabella; Giancarlo Jommi; Roberto Pagliarin; Guido Sello; Massimo Sisti
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 515 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A short and convenient asymmetric synthesis of cl-alkyl a-amino acids is described, using (S)(-)-I-dimethoxymethyl-Z-methoxymethyl pyrrolidine (5) as chiral auxiliary reagent.
For the purpose of practical preparations of a variety of enantiomerically pure uncommon ¢x-amino acids, alkylations of the chiral glycine equivalent 5, which possesses axially chiral binaphthol as an auxiliary, with several electrophiles were investigated. The alkylation proceeded smoothly in satis
A general protocol for the synthesis of a-amino-a-alkyl phosphonic acids in either enantiomeric form is described based on the alkylation of chiral bicyclic phosphonamides derived from (R,R)and (S,S)-1,2diaminocyclohexane. 2 CSu Br(CH&Br. 2. NaN,, DMF,140% Me Y Es& 70-75% (4) 4 h., 95%. (3) 2 Y= Cl
A method is described for the synthesis of a-chloro-a-alkyl-and a-methyl-a-alkylphosphonic acids in either enantiomeric form and in high optical purity, based on the asymmettic allrylation of a-substituted bicyclic phosphonamides derived from a C2 symmetrical diamine.