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Synthesis of γ-and δ-lactones derived from 4-quinolone-3-carboxylic acid

✍ Scribed by Claire Clémencin-Le Guillou; Sylviane Giorgi-Renault; Jean-Charles Quirion; Henri-Philippe Husson

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
234 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

New quinolones 3, 6 and 9 mmelated to either a 5-raembered or a 6-membered lactone were designed as hybrids of antibacterial 4-quinolones and antitumor epipodophyllotoxin derivatives. They were synthezised using ethyl 2-ethenyl-4-hydroxy-l,2-dihydroquinoline-3-carboxylate 2 as a key intermediate.

📜 SIMILAR VOLUMES

Tautomerism and acidity in 4-quinolone-3
Tautomerism and acidity in 4-quinolone-3-carboxylic acid derivatives
✍ Angeles de la Cruz; José Elguero; Pilar Goya; Ana Martínez; Wolfgang Pfleiderer 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 823 KB

hototropic tautomerkm in 4-quinolone-3-carboxylic acid derivatives has been studied with particular emphasis on the intluence of the ring substituents on the equilibrium. The techniques used include W. 1H-NMR. 13C-NMR (soluttonl and 13C-NMR CP/MAS (solid state) and semiempirical and ab tnltio calcul

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