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Synthesis of β-Substituted Alkylamines via Alkylation of N,N-Disubstituted Amides

✍ Scribed by Gassman, Paul G.; Fox, B. Lawrence

Book ID
120579004
Publisher
American Chemical Society
Year
1966
Tongue
English
Weight
295 KB
Volume
31
Category
Article
ISSN
0022-3263

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Parallel synthesis of 1,2,4-trisubstitut
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✍ James M. Cobb; Neil Grimster; Nawaz Khan; Justine Y.Q. Lai; Helen J. Payne (née 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 154 KB

The synthesis of 1,2,4-trisubstituted imidazoles was demonstrated via the solid phase synthesis of N-alkyl-N-(bketo)amides using a carbazate linker. The approach enabled the assembly of a diverse number of N-alkyl-N-(b-keto)amide intermediates in good yield and purity. Subsequent cyclisation in solu