Synthesis of fluorine-18 labeled sulfonu
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Grace G. Shiue; Ralf Schirrmacher; Chyng-Yann Shiue; Abass A. Alavi
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Article
📅
2001
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John Wiley and Sons
🌐
French
⚖ 551 KB
## Abstract Tolbutamide (**1**) and glyburide (**7**) are hypoglycemic drugs used to stimulate insulin secretion in type **2** diabetic patients. We have synthesized their fluorine‐18 labeled analogs, 1‐[(4‐[^18^F]fluorobenzenesulfonyl)]‐3‐butyl]urea (__p__‐[^18^F]fluorotolbutamide, **3a**) and N‐{