𝔖 Bobbio Scriptorium
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Synthesis of β-cell imaging agents

✍ Scribed by C-Y. Shiue; A. Schmitz; M. T. Pourdehnad; G. G. Shiue; R. Schirrmacher; M. Vatamaniuk; N. Doliba; F. Matschinsky; B. Wolf; A. Alavi


Book ID
112132847
Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
153 KB
Volume
44
Category
Article
ISSN
0022-2135

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Synthesis of fluorine-18 labeled sulfonu
✍ Grace G. Shiue; Ralf Schirrmacher; Chyng-Yann Shiue; Abass A. Alavi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 551 KB

## Abstract Tolbutamide (**1**) and glyburide (**7**) are hypoglycemic drugs used to stimulate insulin secretion in type **2** diabetic patients. We have synthesized their fluorine‐18 labeled analogs, 1‐[(4‐[^18^F]fluorobenzenesulfonyl)]‐3‐butyl]urea (__p__‐[^18^F]fluorotolbutamide, **3a**) and N‐{