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Synthesis and evaluation of fluorine-18 labeled glyburide analogs as β-cell imaging agents

✍ Scribed by A Schmitz; C.-Y Shiue; Q Feng; G.G Shiue; S Deng; M.T Pourdehnad; R Schirrmacher; M Vatamaniuk; N Doliba; F Matschinsky; B Wolf; F Rösch; A Naji; A.A Alavi

Book ID
116798747
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
314 KB
Volume
31
Category
Article
ISSN
0969-8051

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## Abstract Tolbutamide (**1**) and glyburide (**7**) are hypoglycemic drugs used to stimulate insulin secretion in type **2** diabetic patients. We have synthesized their fluorine‐18 labeled analogs, 1‐[(4‐[^18^F]fluorobenzenesulfonyl)]‐3‐butyl]urea (__p__‐[^18^F]fluorotolbutamide, **3a**) and N‐{