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Synthesis, uptake mechanism characterization and biological evaluation of 18F labeled fluoroalkyl phenylalanine analogs as potential PET imaging agents

✍ Scribed by Limin Wang; Wenchao Qu; Brian P. Lieberman; Karl Plössl; Hank F. Kung

Book ID
116799653
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
742 KB
Volume
38
Category
Article
ISSN
0969-8051

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## Abstract __The__ syntheses of adenosine analogues, 2′‐deoxy‐2′‐[^18^F]fluoro‐9‐β‐D‐arabinofuranosyladenine ([^18^F]‐FAA) and 3′‐deoxy‐3′‐[^18^F]fluoro‐9‐β‐D‐xylofuranosyladenine ([^18^F]‐FXA) are reported. Adenosine (**1**) was converted to its methoxytrityl derivatives **2** and **3** as a mixt