Synthesis of 18F-labeled cyclooxygenase-
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Haibin Tian; Zhenghong Lee
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Article
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2006
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John Wiley and Sons
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French
β 144 KB
A new PET tracer for COX-2 imaging, the 6-ethoxy-3-(4-methanesulfonylphenyl)-4-(4-[ 18 F]fluorophenyl)pyran-2-one ([ 18 F]EFMP), was synthesized. For F-18 radiolabeling, a trimethylammonium precursor and a brominated precursor were synthesized from 1,1,2,3-tetrachlorocycloprop-2-ene in 6 steps. The