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Systematic screening of potential β-cell imaging agents

✍ Scribed by Ian R Sweet; Daniel L Cook; Åke Lernmark; Carla J Greenbaum; Angela R Wallen; Erin S Marcum; Svetlana A Stekhova; Kenneth A Krohn

Book ID
116287859
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
151 KB
Volume
314
Category
Article
ISSN
0006-291X

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## Abstract Tolbutamide (**1**) and glyburide (**7**) are hypoglycemic drugs used to stimulate insulin secretion in type **2** diabetic patients. We have synthesized their fluorine‐18 labeled analogs, 1‐[(4‐[^18^F]fluorobenzenesulfonyl)]‐3‐butyl]urea (__p__‐[^18^F]fluorotolbutamide, **3a**) and N‐{