Synthesis of α-substituted γ,δ-unsaturated β-oxo esters
✍ Scribed by J. A. M. van den Goorbergh; A. van der Gen
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 647 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0165-0513
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📜 SIMILAR VOLUMES
g-Substituted a,b-unsaturated d-lactams 1 was synthesized from a-sulfinyl acetamides 3 in three steps. Formal synthesis of (±)-protoemetinol was also reported.
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An enantioselective synthesis of a,b-unsaturated gand d-lactams was proposed based on a simple strategy using the initial preparation of cis vinylogous aminoesters by the Horner reaction followed by a mild intramolecular cyclisation.