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An efficient synthesis of γ-substituted α,β-unsaturated-δ-lactams. Formal synthesis of (±)-protoemetinol

✍ Scribed by Chang-Gin Huang; Bo-Rui Chang; Nein-Chen Chang

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
100 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

g-Substituted a,b-unsaturated d-lactams 1 was synthesized from a-sulfinyl acetamides 3 in three steps. Formal synthesis of (±)-protoemetinol was also reported.

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Enantioselective synthesis of α,β-unsatu
Enantioselective synthesis of α,β-unsaturated γ- and δ-lactams
✍ Claude Grison; Stéphane Genève; Philippe Coutrot 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 89 KB

An enantioselective synthesis of a,b-unsaturated gand d-lactams was proposed based on a simple strategy using the initial preparation of cis vinylogous aminoesters by the Horner reaction followed by a mild intramolecular cyclisation.