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Enantioselective synthesis of α,β-unsaturated γ- and δ-lactams

✍ Scribed by Claude Grison; Stéphane Genève; Philippe Coutrot

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
89 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

An enantioselective synthesis of a,b-unsaturated gand d-lactams was proposed based on a simple strategy using the initial preparation of cis vinylogous aminoesters by the Horner reaction followed by a mild intramolecular cyclisation.

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1,4-Reductive Addition of Hydrazoic Acid to γ-Oxo-α,β-unsaturated δ-Lactones and -Lactams: A Convenient Route to α-Amino-γ-oxo-α,β-unsaturated δ-Lactones and -Lactams
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γ-Oxo-α,β-unsaturated δ-lactones and lactams, which are in high yields, of the corresponding α-amino-γ-oxo-α,βunsaturated δ-lactones and -lactams, compounds of great easily accessible from their corresponding 2-furylcarbinols, were used as substrates for the 1,4-reductive addition of biological and