Synthesis of α-dicarbonyl compounds from N-acyl α-aminoketones
✍ Scribed by S. I. Zav'yalov; G. I. Ezhova
- Book ID
- 112449886
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 492 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1573-9171
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📜 SIMILAR VOLUMES
Reduction of acyl cyanides with zinc in acetic acid in the presence of excess acetic anhydride leads to N-acetyl-cr-aminoketones in good yields. An efficient three-step synthesis of 5-aminolevulinic acid by this method is described. a-Aminoketones are versatile difunctional compounds. They have fou
## Abstract A series of optically active __N__‐protected α‐aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the __N__‐__tert__‐butoxycarbonyl amino acids. Reduction of the α‐aminoketones by sodium borohydride resulted in the corresponding 1,2‐amino alcohols. © 2003 W