Synthesis of α-aminoketones via selective reduction of acyl cyanides

✍ Scribed by Andreas Pfaltz; Saeed Anwar

• Book ID: 104233709
• Publisher: Elsevier Science
• Year: 1984
• Tongue: French
• Weight: 215 KB
• Volume: 25
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)81341-1

✦ Synopsis

Reduction of acyl cyanides with zinc in acetic acid in the presence of excess acetic anhydride leads to N-acetyl-cr-aminoketones in good yields. An efficient three-step synthesis of 5-aminolevulinic acid by this method is described.

a-Aminoketones are versatile difunctional compounds. They have found a wide range of