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Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

✍ Scribed by Subash C. Jonnalagadda; Jonathan S. Cruz; Ryan J. Connell; Patricia M. Scott; Venkatram R. Mereddy

Book ID
104096607
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
757 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.

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Synthesis of carboranyl derivatives of alkynyl glycosides as potential BNCT agents
✍ Giovanni Battista Giovenzana; Luigi Lay; Diego Monti; Giovanni Palmisano; Luigi 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 666 KB

A series of amphiphilic carbohydrate-carborane hybrids consisting of a lipophilic core (carborane cage) and a glycoside moiety for conferring high-affinity recognition by the cellular lectins have been prepared in a chemically accessible fashion.