## Abstract A library of 19 cycloruthenated derivatives is constructed by making use of the wellβknown cyclometalation reaction. Their geometries are modified in a straightforward manner by addition of either monoβ or bidentate ligands, such as bipyridine, phenanthroline, 1,2βbis(diphenylphosphanyl
Synthesis of Functionalized Carboranes as Potential Anticancer and BNCT Agents
β Scribed by Reddy, Venkata Jaganmohan; Roforth, Matthew M.; Tan, Chalet; Reddy, M. Venkat Ram
- Book ID
- 120442436
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 133 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0020-1669
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π SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
A series of amphiphilic carbohydrate-carborane hybrids consisting of a lipophilic core (carborane cage) and a glycoside moiety for conferring high-affinity recognition by the cellular lectins have been prepared in a chemically accessible fashion.
Novel Ξ±-carboranyl-Ξ±-acyloxy-amides were prepared as potential BNCT agents utilizing three component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as