Novel Ξ±-carboranyl-Ξ±-acyloxy-amides were prepared as potential BNCT agents utilizing three component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as
β¦ LIBER β¦
Synthesis of carboranyl derivatives of alkynyl glycosides as potential BNCT agents
β Scribed by Giovanni Battista Giovenzana; Luigi Lay; Diego Monti; Giovanni Palmisano; Luigi Panza
- Book ID
- 104209720
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 666 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
β¦ Synopsis
A series of amphiphilic carbohydrate-carborane hybrids consisting of a lipophilic core (carborane cage) and a glycoside moiety for conferring high-affinity recognition by the cellular lectins have been prepared in a chemically accessible fashion.
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