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Synthesis of wiedendiol-A and wiedendiol-B from labdane diterpenes

✍ Scribed by Alejandro F. Barrero; Enrique J. Alvarez-Manzaneda; Rachid Chahboun

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 844 KB
Volume: 54
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(98)00235-x

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✦ Synopsis

Two efficient enantiospecific syntheses of wiedendioI-A (1) from (-)-sclareol (7), via I 1-bromo-8-drimene (I!) and 8-drimen-1 i-al (3), are reported. The first enantiospecific synthesis of wiedendioI-B (2), via 8S.9S-driman-! l-al (26), by two alternative mutes starting from 7 and (+)-cisabienol (8) is also described. 21 prepared from protocatechualdehyde (17) was used as aromatic synthon for preparing 1 and 2.

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