Wiedendiol-A and -B, cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri

✍ Scribed by Stephen J. Coval; Michael A. Conover; Ronald Mierzwa; Arthur King; Mohindar S. Puar; David W. Phife; Jin-Keon Pai; Robert E. Burrier; Ho-Sam Ahn; George C. Boykow; Mahesh Patel; Shirley A. Pomponi

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 399 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00081-4

✦ Synopsis

Wiedendiol-A and -B, novel sesquiterpene-hydroquinones which inhibit cholesteryl ester transfer protein (CETP), have been isolated from the marine sponge Xestoepongia wiedenmayeri. Additional related marine natural products were also evaluated for CETP inhibition. Compounds that inhibit the activity of CETP may find utility as antiatherosclerosis therapy.