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An efficient synthesis of Wiedendiol-A from (+)-sclareolide

โœ Scribed by Samuel Chackalamannil; Yuguang Wang; Yan Xia; Michael Czarniecki


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
164 KB
Volume
36
Category
Article
ISSN
0040-4039

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The fmt enantiospecificsynthesisof the cholesterolester mansferprotein (CETP)inhibitorwiedendiol-B(1) is described.The drimanicsyntbonwas prepared from(-)-sclareol( 4) and (+)-cis-abienol ( 13)by two akernativeroutes.The key steps of the reactionsequencesare the chemo-anddisstereoselectivehydrogenat