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Synthesis of tyrosine3-lysine8-vasopressin

✍ Scribed by H. C. Beyerman; J. S. Bontekoe

Book ID
104586236
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
277 KB
Volume
79
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

The synthesis is described of the protected linear nonapeptide: N‐benzyloxycarbonyl‐S‐benzyl‐L‐cysteinyl‐L‐tyrosyl‐L‐tyrosyl‐L‐glutammyl‐L‐asparaginyl‐S‐benzyl‐L‐cysteinyl‐L‐prolyl‐N^e^‐p‐toluenesulfonyl‐L‐lysylglycineamide (II, Fig. 2) in analytically pure form.

Removal of the blocking groups from II, followed by cyclization through oxidation, yielded a preparation assumed to contain an analogue of lysine^8^‐vasopressin with L‐phenylalanine replaced by L‐tyrosine (Fig. 1).

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