Synthesis of tyrocidine a: Use of oxime resin for peptide chain assembly and cyclization
✍ Scribed by George Ösapay; Adam Profit; John W. Taylor
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 260 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
N-Methyloctadepsipeptides attached to an oxime resin were cyclized by heating them in refluxing ethyl acetate for 2 days to give cyclooctadepsipeptide PFI022A analogs.
Resin-bound peptides can be cleaved from the Kaiser oxime resin using the tetra-nbutylammonium salts of side-chain protected amino acids to directly provide the a-aminoprotected (Boc), side-chain protected peptide. Complete experimental details are provided. The protected peptide fragments can be pu
The use ofnucleophiles for the cleavage of an o-nitrobenzylester peptide-resin bond in order to afford peptide alkylesters and alkylamides has been studied. With this purpose, three short peptide sequences anchored to a Nbb-resin were used as models. Peptides were cleaved from the polymeric supports