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A practical method for the preparation of protected peptide fragments using the Kaiser oxime resin

✍ Scribed by Peter T. Lansbury Jr.; Julia C. Hendrix; Annemarie I. Coffman

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
264 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

Resin-bound peptides can be cleaved from the Kaiser oxime resin using the tetra-nbutylammonium salts of side-chain protected amino acids to directly provide the a-aminoprotected (Boc), side-chain protected peptide. Complete experimental details are provided. The protected peptide fragments can be purified and used for fragment coupling synthetic strategies.

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