𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Two Acridine Conjugates of the Bis(phenanthroline) Ligand “Clip-Phen” and Evaluation of the Nuclease Activity of the Corresponding Copper Complexes

✍ Scribed by Steven A. Ross; Marguerite Pitié; Bernard Meunier

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
287 KB
Volume
1999
Category
Article
ISSN
1434-1948

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis of three novel derivatives [N-acetyl-Clip-Phen relative to the parent complex [Cu(Clip-Phen)] 2+ . However, the acridine-containing complexes [Cu(4)H] 3+ and [Cu(5)H] 3+ (1), Clip-Phen-hexylaminoacridine (4) and Clip-Phenhexylchloromethoxyaminoacridine ( )] of the bis(phen-exhibited significantly enhanced cleavage efficiencies, which has been attributed to increased affinity of the anthroline) ligand "Clip-Phen", are described. Complexation of these ligands with copper(II) afforded the 1:1 complexes complexes for DNA. UV/Vis-spectral data of the complexes in the presence of calf-thymus DNA was consistent with an as hexafluorophosphate salts. The relaxation of φΧ 174 DNA was used as a DNA cleavage assay, with the following intercalative mode of binding. results. [Cu(1)] 2+ was found to show a diminished activity calation of polyaromatic species between adjacent base

📜 SIMILAR VOLUMES

Synthesis and Structure of the Copper(II
Synthesis and Structure of the Copper(II) Complex of a Chiral Bis(dihydrooxazole) Ligand
✍ Jonathan Hall; Jean-Marie Lehn; André DeCian; Jean Fischer 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 German ⚖ 351 KB 👁 1 views

424 of the CNRS. Whilst this manuscript was in preparation, a similar example of the synthesis of chiral bis(dihydrooxazo1es) appeared in the literature [7]. HELVETICA CHIMICA ACTA -Val. 74 (1991) Scheme I 1 phl"' 76% CH,OSiMe,( f-Bu) a ) EtOH, HCl, dioxane, 18 h. b ) (+)-(1S,2S)-2-Amino-l-phenylpro

Synthesis, crystal structure and magneti
Synthesis, crystal structure and magnetic properties of the binuclear copper (II) complex of a new bis (1, 4, 7, 10-tetraazacyclododecane) ligand
✍ Xu Qiang; Du Miao; Zhang Ruo-Hua; Shen Hao-Yu; Bu Xian-He; Bu Wei-Ming 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 408 KB 👁 2 views

Synthesis, crystal structure and magnetic properties of the binuclear copper ( 11) complex of a new bis ( 1 , 4 7 10-tetraazacyclododecane) ligand help to elucidate the factors that determine the electronic and magnetic pruperties in the polynuclear bio-site. The ligands that comprise two macmycles

The Design of Metal Chelates with a Biol
The Design of Metal Chelates with a Biologically Related Redox-Active Part: Conjugation of Riboflavin to Bis(2-pyridylmethyl)amine Ligand and Preparation of a Ferric Complex
✍ Nasser K. Thallaj; Dominique Mandon; Kristen A. White 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB

## Abstract Reaction of a twofold molar excess of bis(2‐pyridylmethyl)amine DPA with 8α‐bromoAc4riboflavin in dry DMF over 24 h affords the 8α‐[bis(2‐pyridylmethyl)amine]‐__N__‐Ac~4~riboflavin ligand. This compound can be described as a tweezer in which the flavin moiety acts as a potential electro

Synthesis of Silver(I) Complexes with th
Synthesis of Silver(I) Complexes with the Bis(diphenylphosphanyl)-o-carborane Ligand. Crystal Structure of [Ag(phen){(PPh2)2C2B10H10}]ClO4 and [Ag{(SPPh2)2CH2}{(PPh2)2C2B10H10}]ClO4 · CH2Cl2
✍ Bembenek, Eberhard ;Crespo, Olga ;Concepción Gimeno, M. ;Jones, Peter G. ;Laguna 📂 Article 📅 1994 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 549 KB

Silver(1) complexes I Bis(diphenylphosphany1)-o-carborane I o-Carborane Silver(1) perchlorate or nitrate react readily with bis(di-phenylphosphany1)-o-carborane to give the complexes [AgX((PPh2)2C2BloHlo)1 [X = C104 (l), NO3 (2)]. The perchlorate ligand is weakly bound to the silver atom and thus ca