The Design of Metal Chelates with a Biologically Related Redox-Active Part: Conjugation of Riboflavin to Bis(2-pyridylmethyl)amine Ligand and Preparation of a Ferric Complex
✍ Scribed by Nasser K. Thallaj; Dominique Mandon; Kristen A. White
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 94 KB
- Volume
- 2007
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
Abstract
Reaction of a twofold molar excess of bis(2‐pyridylmethyl)amine DPA with 8α‐bromoAc4riboflavin in dry DMF over 24 h affords the 8α‐[bis(2‐pyridylmethyl)amine]‐N‐Ac~4~riboflavin ligand. This compound can be described as a tweezer in which the flavin moiety acts as a potential electron mediator. The trichloroferric complex has been prepared, and together with the low potential reduction wave of the flavin moiety, the presence of a reversible Fe^III^/Fe^II^ couple at a higher potential is observed. The deacetylated ligand 8α‐[bis(2‐pyridylmethyl)amine]‐N‐riboflavin can easily be obtained. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)